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What are the consequences of disturbed venous back flow of the blood?

When veins change their appearance and become varicose, they lose the capability of adapting to different levels of blood volume. The veins remain permanently enlarged, the valves do not close anymore. The return transport of the blood to the heart is disturbed, the blood flows backwards and pools in the veins. In the cutis and subcutis, there are accumulations of interstitial fluid and metabolic end-products that are not removed. The recognizable consequences of this disordered condition are described as chronic venous insufficiency, which finally leads to the development of venous leg ulceration.